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Endothelial cells play a fundamental role in chronic oxidative stress and the development of atherosclerosis, thrombosis and lung injury, principal complications of SARS-CoV-2-mediated tissue and organ dysfunction (Chang et al., 2021)

When ROS levels rise and threaten the homeostatic processes of the human body, endogenous antioxidants are activated

It has been shown to target Yin Yang 1 (Yy1), a transcription factor that influences the expression of FAS [318]

Importantly, NBDHEX is also able to dissociate GSTP1-1 from its complexes with both JNK and TRAF2, thus enabling their activation 99

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