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In HCC, metabolic reprogramming that restricts intracellular -KG availability compromises the dynamic responsiveness of regulatory chromatin, particularly at enhancer regions governing hepatocyte differentiation and tumor-suppressive signaling

Liu M, Gu Y, Ma J-N, Bao K-N, Ao L, Ni X (2022) An updated analysis on the association of GSTM1 polymorphism and smoking exposure with the increased risk of coronary heart disease

Metabolomic analyses have revealed alterations in metabolite profiles consistent with increased anabolic activity and altered energy body function

For example, ginsenosides Rb1, Rg1, Rb3, CK and GSE play a protective role in myocardial injury by inhibiting ROS expression and restoring mitochondrial membrane potential, thus maintaining mitochondrial integrity