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These results highlight the potential harmful effects of microplastic exposure on cognitive outcomes in children ( Polyethylene terephthalate (PET) nanoparticles accelerate amyloid fibril formation and alter the secondary structure of A fibrils, these findings further suggest that accumulation of PET nanoparticles in the brain promotes the progression of multiple neurodegenerative diseases, including Alzheimers disease ( Transmission electron microscopy and molecular dynamics simulations demonstrated that polystyrene nanoplastics accelerate A aggregation through the formation of protein coronas, facilitating peptide fibrillization via hydrogen bonding and interactions, flow cytometry and endocytosis inhibition assays revealed that polystyrene nanoplastics impair microglial uptake of A while enhancing their own cellular internalization, leading to microglial energy exhaustion and allowing A aggregates to escape immune clearance

Although we used a mild STZ-induced diabetic mouse model that mimics certain aspects of type 2 diabetes, the inclusion of additional insulin-resistant or diet-induced models in future studies could enhance generalizability

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Includes: bottom equalizer connection, flume box equalizer connections for equalization of the two cold water basins