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17 The COMBO-DN study found that drug combinations did not significantly outperform high-dose monotherapy

The average age of diagnosis is approximately 28 years (2)

Recently, the anti Siglec-8 antibody lirentelimab showed promising results in ISM

Secondly, several cell- and growth factor-based regenerative treatment strategies have been tested in vitro and in vivo in animal models with experimentally induced IVD degeneration