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Cuando las clulas comienzan con la fase de proliferacin, se observan niveles altos de GSH en el ncleo, en tanto que las clulas en reposo tienen niveles de GSH similares o ms bajos en el ncleo respecto al citoplasma (22)

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It is also inevitable that biological functions decline due to ROS and reactive nitrogen species generated from our reliance on oxygen [62]

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Nevertheless, there is a problem: complete inhibition of autophagy by inducible whole-body knockout of the core autophagy factor ATG7 is lethal in mice (Karsli-Uzunbas et al., 2014), suggesting the strong likelihood of unacceptably severe side effects if autophagy inhibition were to be tried in human cancer patients