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Matrixyl has an extensive cosmetic safety record, with adverse event data from decades of consumer use indicating low irritation potential and no documented systemic effects at cosmetic concentrations

T., & Witthft, C

J Cell Sci (2004) 117(Pt 20):477986

10.1002/cam4.991 121 SteffesV

Studies in cats show that the bioavailability of SC administered buprenorphine in recommended doses is very low, individual variability high, and clinical efficacy poor [16, 17, 22]