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36 Silybum Marianum The active components of Silybum marianum (milk thistle), silymarin and silibinin, exhibit anti-cancer effects in HCC by targeting key signaling pathways including HGF/c-Met, Wnt/-catenin, and PI3K/Akt/mTOR

doi: 10.7150/thno.73650 8 SandsBEIrvingPMHoopsTIzanecJLGaoLLGasinkCet al

Treatment of breast cancer cell lines with 28-homocastasterone (28-homoCS) and 24-epibrassinolide (24-epiBL) has been associated with reduced expression of cyclins involved in the G1 phase of the cell cycle

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Growth factor modulation: It enhances the activity of growth hormone receptors, fibroblast growth factor, and EGF, all critical to tissue repair