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MarinescoSjgrens syndrome (MSS) is a rare genetic disorder characterised by cerebellar ataxia caused by degeneration of Purkinje neurons, muscle weakness, hypotonia and ocular cataracts, although several other symptoms have been reported, including bone abnormalities and cognitive impairment

Studies have continually demonstrated a strong link between a dietary reliance on cyanogenic cassava coupled with general malnutrition, however, these risk factors are present in many regions of sub-Saharan Africa where konzo does not occur 5,24,25

Biocatal Agric Biotechnol 60:103298

doi: 10.1038/nm.4333 106 CullisJDasSBar-SagiD

The two top-most significantly changed oxidized cysteine residues in tumors were Cys 156 of caveolin-1 (CAV1) and Cys 240 of receptor of activated protein C kinase 1 (RACK1) (Fig