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Metformin should be temporarily discontinued at the time of or prior to procedures involving iodinated contrast media in patients with eGFR 30-60 mL/min/1.73 m or other risk factors for acute kidney injury

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Additionally, R5P can be converted into glyceraldehyde-3-phosphate and fructose-6-phosphate (F6P), with the latter being able to isomerize back to G6P (Wamelink et al., 2008)