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Standard laboratory assays measure total serum B12, which includes vitamin bound to transport proteins

(2023) reported three families with focal epilepsy and identified three novel heterozygous germline mutations in the NPRL3 gene through linkage analysis, whole-exome sequencing, and Sanger sequencing

10.1016/j.jpeds.2021.12.049 8

New insights into oxidative and reductive stress responses and their relation to the anticancer activity of selenium-containing compounds as hydrogen selenide donors

The second is pharmacological: what side effects, treatment burden, and long-term trade-offs come with using medication to push levels that low