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The developmental nature of metabolic changes in ASD has been attributed in part to a delayed maturational program 10,11,12 , which in turn, is coupled to corresponding developmental changes in brain structure and function, immunity, the microbiome, and the autonomic nervous system 4,13,14,15

Using mouse kidney cells, which are known to have GSH transporters, as a model, it was further demonstrated that COXP DiR micelles entered the cells in an energy dependent mechanism and the penetration was inhibited by probenecid consistent with a GSH transporter-mediated process [52]

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Acknowledgements The authors would like to acknowledge the financial assistance received from National Institute of Pharmaceutical Education and Research (NIPER), S.A.S