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Aging Cell 23 , e14102 (2024)

When ARA-290 binds to the IRR, it does two critical things: It shuts down inflammation: It tells the immune system to stop attacking the damaged area, switching the focus from "defense" to "reconstruction." It stimulates regeneration: It promotes the sprouting of small nerve fibers, which are often the first to die in conditions like Small Fiber Neuropathy (SFN)

Abeta promotes CD38 expression in senescent microglia in Alzheimers disease

Maintains healthy nervous system function

The most common players in the lab are: Dimethyl sulfoxide (DMSO) Dimethylformamide (DMF) Acetonitrile (ACN) The trick here is to be strategic