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In adults, somatomedin alteration contributes to increased osteoclast activity, resulting in weaker bones that are more prone to pathologic fracture and osteoporosis

Initial Metabolic Changes (Days 1-14): While cellular-level metabolic changes begin within hours of the first AOD-9604 administration, noticeable subjective effects typically emerge within the first one to two weeks

The starting dose for severe deficiency is typically 1500mcg (the full dose of the 1ml vial) given daily or on alternate days for 1 to 2 weeks, or until haematological remission is achieved

Researchers designing protocols based on this escalation data should reference the published Phase 2 data while monitoring Phase 3 publications for refinements