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Given that these reducing equivalents are indispensable for cellular redox homeostasis and energy metabolism, an imbalance of the redox state of these molecules is implicated in a variety of pathological conditions, such as cardiovascular diseases, neurodegenerative diseases, cancer, and aging (10, 115)

However, despite these studies showcasing the bioactivity of catechins, their clinical efficacy may be limited due to their low bioavailability in vivo

Their efficacy and pharmacokinetic advantages have been repeatedly demonstrated, clinical translation is limited by uncertainties around cytotoxicity, immunogenicity, and long-term accumulation

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Molecules 28 , 3460 (2023)