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Moreover, in a study using a nonobese prediabetic rat model, the increased phosphorus content in the diet, which is known to increase 2,3-DPG (21) , was associated with a reduction in hypoxia-inducible factor-1 in the perivascular adipose tissue (154)

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Instead, its primary function lies in catalyzing the transfer of electrons from cytochrome c to the final electron acceptor, O 2 , leading to the production of H 2 O

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Ye Z, Wang S, Zhang C, et al