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These observations further suggest that there is increased systemic inflammation upon estrogen-deprivation in OVX animals as evident by the reversal of NO level in the OVX+E2 animal groups

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However, the success of maintenance therapy depends on the vulnerability of the treated tumor, its inability to develop cross-resistance mechanisms during the cytotoxic assault by the drug and conversely, the presence of robust defense mechanisms in healthy tissue to mitigate the drugs side effects

Furthermore, mycotoxins can alter the composition and diversity of the gut microbiota, affecting the balance of beneficial and pathogenic microorganisms