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An interesting study aiming to evaluate the impact of the flavonoids quercetin, naringenin and naringin on the metabolism of cultured human macrophages has highlighted that the flavonoid-mediated immunomodulation derived from glycolytic downregulation, as well as anti-inflammatory reprogramming of the TCA cycle and antioxidant protection (mainly quercetin), membrane modification (naringenin) and osmoregulation (naringin) (129)

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