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Further oxidation of Hz and AcHz by CYP450 enzymes, particularly CYP2E1, generates reactive intermediates that form covalent adducts with endogenous macromolecules, a process implicated in INH-induced hepatotoxicity (Delaney and Timbrell, 1995

Enzymatic production of -L-glutamyltaurine through the transpeptidation reaction of -glutamyltranspeptidase from Escherichia coli K-12

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