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PI3K/Akt/mTOR Signaling Cascade A primary downstream pathway of IGF-1R activation is the PI3K/Akt/mTOR cascade, which regulates cell survival, protein synthesis, and metabolic homeostasis

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doi: 10.3389/fmolb.2022.964624 Received 08 June 2022 Accepted 11 July 2022 Published 26 August 2022 Volume 9 - 2022 Edited by Giuseppe Calamita, University of Bari Aldo Moro, Italy Reviewed by Umberto Laforenza, University of Pavia, Italy Paul Yancey, Whitman College, United States Updates Copyright 2022 Ilyas, Wijayasinghe, Khan, El Samaloty, Adnan, Dar, Poddar, Singh, Sharma and Khan

It was originally FDA-approved in 1997 for diagnosing and treating growth hormone deficiency in children