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Sun et al concluded that, among patients with diabetic neuropathy, treatment with both combination agents and pure methylcobalamin appeared to improve the symptoms rather than electrophysiologic results.(9) Other good-quality studies have been published since 2006, warranting an updated review on this topic

The elucidation of signaling pathways involved in the regulation of the tight junction would allow the identification of novel barrier-restoring agents, which is imperative for deciphering novel and potent approaches for disease treatment

This form of vitamin B12 promotes protein synthesis for maintaining healthy nerve cells and myelin

V., Romano-Silva, M

Additionally, in this group, a linear relationship existed between the observed change in CNFD and the change in symptoms for the ARA 290 subjects as assessed by PainDetect (Figure 6)