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Description

EGCG and exercise, either separately or in combination, are applied to a 2-month mouse, with the impact of a 4-month wheel-running exercise attenuating or lowering the formation of soluble A142 levels in the cortex and hippocampus [40]

This isoform carries a 10-fold lower affinity for pituitary activin compared to FS-288, and by avoiding cell surface binding through heparan sulphate proteoglycans, it circulates systemically making it the preferred isoform for muscle-targeted research applications where minimising reproductive axis interference is a priority