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High (variant is assumed to have disruptive impact in the protein: stop codon gained and loss of function), low (harmless or unlikely to change protein behavior: synonymous codon), moderate (non-disruptive variant that might alter protein effectiveness: missense codon and inframe codon loss) and modifier (non-coding variants or variants affecting non-coding genes: exon variant and downstream gene variant) are parameters used by SnpEff to correlate SNPs and their putative impact on protein functioning

1031,1032,1033,1034 FASN continues to be a critical focus for new cancer therapies, with research efforts geared toward maximizing efficacy while minimizing adverse effects

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Thus, Bcl2-family proteins control mitochondrial integrity, regulate cytochrome c release and intrinsic apoptosis (Youle and Strasser, 2008)