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Iron overload augments the development of atherosclerotic lesions in rabbits

These converging pathways suggest that future interventions might achieve enhanced efficacy by simultaneously targeting inflammation, neural repair, and microbiota balance

Furthermore, it is evidenced by the work mentioned above that the use of rodent and other complimentary models is an important tool for the study of mechanisms of Mn toxicity, focusing on Mn transport, metal homeostasis, behavioral outcomes and neuroprotective strategies