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It is structurally distinct from IGF-1 LR3 and acts through what some researchers describe as an MGF-specific receptor pathway, although the precise receptor identification remains debated in the published literature

In hypogonadotropic hypogonadism, decreased levels of GnRH, FSH, and/or LH result in impaired testicular function, often leading to low energy and infertility in reproductive-aged men

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