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First, the molecular trigger specificity of oxalate-induced ferroptosis in renal tubular cells is undefinedhow oxalate precisely initiates the synergistic dysregulation of iron uptake (TFR1), lipid metabolism (ACSL4), and antioxidant defense (GPX4/SLC7A11) remains elusive, with no clarity on upstream signaling molecules or post-translational modifications that link oxalate exposure to ferroptosis machinery

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doi: 10.1016/j.fct.2018.06.054

Tanoue A, Ito S, Honda K, Oshikawa S, Kitagawa Y, Koshimizu TA et al (2004)