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The authors thank the Ingredients Department (Shanghai Jiyan Biomedical Development Co., Ltd.) for their support in transdermal permeation experiments

Changes in brain metabolism might contribute to these phenotypes, as many of the deleted genes are involved in metabolic processes, but this is unknown

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In the SURMOUNT trials, night sweats were more common during dose escalation phases (when patients moved from 2.5 mg to 5 mg to 10 mg weekly injections) rather than at maintenance doses