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Again, elevated levels of 8-OHdG have been linked to disease severity in various conditions, including cardiovascular disease (188), chronic periodontitis (189), Huntingtons disease (190), chronic kidney disease (191), and colorectal tumors (192194)

& Ruiz-Meana, M

PMID 14628964

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Additionally, the si-TRPM7 and TPEN treatment significantly reduced the up-regulation of ROS (Fig