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Trials to fit a horseshoe shaped molecule, as has been observed both in LTC4S (PDB ID: 2UUH and 2PNO) and MPGES1 (PDB ID: 3DWW and 4AL0), were not successful and led to reduction of refinement statistical criteria

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Lesions with a very low rate of bone formation have been described in patients with avascular necrosis

Specifically, oleanolic acid functions as an epigenetic modulator that blocks the IL-1/NF-B/TET3 axis in gastric cancer cells, resulting in DNA hypomethylation and programmed cell death ligand 1 downregulation, thereby providing adjuvant therapeutic benefits