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Ferroptosis results from abnormal increased ROS levels that leads to lipid peroxidation, meanwhile the products of lipid peroxidation interact with membrane receptors and transcription factors/repressors to activate intrinsic and extrinsic signaling pathways for apoptosis (Elkin et al., 2018)

October 1317, 2012

[PMC free article] [PubMed] [CrossRef] [Google Scholar] Konishi Y., Hori H., Ide K., Katsuki A., Atake K., Igata R., Kubo T., Tominaga H., Beppu H., Asahara T., et al

The blood brain barrier is not just a physical barrier

The compound is a quinolinium scaffold with a methyl substituent at position 1 and an amino substituent at position 5, supplied as the iodide salt for stability