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doi: 10.1590/s0100-879x2006000200006

Additionally, butyrate regulates gut immune cell function by inhibiting histone deacetylase (HDAC) activity, promoting the differentiation of Treg, and suppressing the release of pro-inflammatory cytokines such as IL-6 and TNF-, thereby alleviating intestinal inflammation [439, 440]

A recent study revealed that mice subjected to 40% CR exhibited several indicators of improved health, including reduced body temperatures, heightened hunger responses, and alterations in their immune repertoire (Di Francesco et al

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Also, the baseline study [20] found that levels of several vitamins, minerals, and amino acids were strongly associated with variation in autism severity