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An initial study with a limited sample size (39 HAPE patients and 43 controls) revealed no role of CYBA in HAPE pathogenesis in Caucasians, 119 but a larger Indian cohort (150 HAPE patients and 180 controls) linked CYBA (rs4673 and rs9932581) and GSTP1 (rs1695 and rs1138272) to elevated circulating 8-iso-prostaglandin F2 in HAPE, potentially contributing to HAPE susceptibility

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1.2 Chronic lung disease NTHi is the leading bacterial cause of infectious exacerbations in adults with chronic obstructive pulmonary disease (COPD) and the second leading cause of infections in paediatric cystic fibrosis (Marshall et al., 2022)

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Genetic and organoid studies demonstrate that Desert Hedgehog and Wnt Family Member 2B (WNT2B) are also required for effective post-irradiation repair