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349 If the ulcers fail to show a 50% reduction after 4 weeks of appropriate management via conventional methods, several advanced therapies, including negative-pressure therapy, growth factor therapy, bioengineered tissue, acellular matrix tissue, stem cell therapy, hyperbaric oxygen therapy, and, most recently, topical oxygen therapy, can be considered

2,10,11 Therefore, targeting ferroptosis to suppress tumor progression remains a challenge, and the development of ferroptosis-inducing agents that target multiple pathways to improve therapeutic efficacy is crucial

However, the related mechanism of blood oxygen content and serum ions in a hypoxic environment must be studied further

A cross-sectional study revealed that serum UA levels were significantly lower in patients with MCI compared to healthy subjects

These treatments are also costly, ranging from $100-$300+ per session, and are not covered by insurance