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Injection delivery achieves near-complete absorption far higher than oral B12 supplements, which depend on intrinsic factor in the gut

This results in muscle fatigue, trigger points, muscle knots, and eventually persistent spasms

In many patients, this is in the wrist where there is damage or deterioration that is causing pain and limiting function

The duration of the trial was three years with 3862 patients exposed to Reclast and 3852 patients exposed to placebo administered once annually as a single 5 mg dose in 100 mL solution infused over at least 15 minutes, for a total of three doses

Currently, there is only one drug in this class of medicationstirzepatide, which is approved as Mounjaro for treatment of Type 2 diabetes and as Zepbound for the treatment of obesity