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Elevated levels of G6PD in ATMs can cause obesity-related inflammation ( de novo lipogenesis (DNL) which promotes hepatic steatosis and insulin resistance ( via NOXs, leading to liver damage and insulin resistance ( Carbohydrate kinase-like protein (CARKL), also known as sedoheptulokinase (SHPK), is a carbohydrate kinase catalyzing the phosphorylation of sedoheptulose to S7P (Figure 2)

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Notably, SOX17 expression was found downregulated in human CCA tumours, correlating negatively with promotor hypermethylation and associated with poorer prognosis due to its tumour suppressor role in CCA 73

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