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Theoretically, there is a possibility of negative effects, including the development of neuropathies due to misdiagnosing cobalamin, the advancement of cancer, and improper CNS development in embryos

Using a melanocyte-specific VDR knockout mouse model, Chagani et al

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Free radicals are natural byproducts of cellular metabolism, but environmental factors like pollution, poor diet, stress, and lack of sleep can dramatically increase their production

In 2018, a Biochemical Pharmacology study reported that membrane-permeable NNMT inhibitors given to obese mice cut white fat mass and body weight and shrank adipocytes [5]