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However, when used for this purpose, clinicians use tramadol for chronic non-cancer pain if there is a documented risk-benefit analysis and initiation of treatment using extended-release tramadol at 100mg by mouth once daily (61)

Figure 1 2 Role of amyloid- accumulation and neuroinflammation Amyloid-beta (A) is a peptide generated through the sequential enzymatic cleavage by -, -, and -secretases of amyloid precursor protein (APP), a transmembrane protein predominantly expressed in neurons