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Under the BPCIA, the first biosimilar to receive interchangeability designation for a reference product earns one year of exclusivity against other interchangeability designations, assuming the first interchangeable product is commercially marketed and no court has found a relevant patent invalid or not infringed

Like tricyclic antidepressants (TCAs), serotoninnorepinephrine re-uptake inhibitors, such as duloxetine, are drugs with a moderate-to-high quality of evidence and a strong recommendation for use in the treatment of neuropathic pain [1,67]