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These cells synthesize the collagen and cartilage that the body uses to repair damaged ligaments and joints

Inflammation Res (2013) 62(9):82334

This oxidative damage impacts protein activity, stability, conformation, and interactions, thereby affecting protein function

Negative ANA : While antinuclear antibodies (ANA) can occasionally be present in up to a third of RA patients, a negative result is clinically useful in ruling out other systemic rheumatic diseases, such as systemic lupus erythematosus (SLE) or mixed connective tissue disease, which can present with similar early joint symptoms but are characterized by specific autoantibodies (Baker, 2026