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Picard M, et al

Brain Res 1241:15767 Sharma AK, Jordan WH, Reams RY et al (2008) Temporal profile of clinical signs and histopathologic changes in an F-344 rat model of kainic acid-induced mesial temporal lobe epilepsy [J]

As for the mechanism by which IGF-1 regulates skeletal growth and maintenance, it has been proposed that the actions of IGF-1 on bone occur through multiple modes: endocrine, autocrine, and paracrine