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In this context, upregulation of VCAM-1 and integrin 4 expression in tumor-associated LECs, due to the presence of tumor-derived inflammatory factors, leads to weakened LEC junctions, further contributing to increased lymphatic permeability and cancer cell penetration into LVs (157) ( Figure 4A )

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Use of inflammatory markers to guide cancer treatment

Biochem J 410:525534 Hong SH, Lee D-H, Lee Y-S et al (2017) Molecular crosstalk between ferroptosis and apoptosis: emerging role of ER stress-induced p53-independent PUMA expression

This is particularly important for essential and abundant proteins whose overoxidation would lead to loss of cell viability and requires new protein synthesis to replace inactivated proteins