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Perhexiline, a CPT1 inhibitor, induces a metabolic shift from fatty acid to glucose oxidation, triggering a complex rebalancing of carbon and nucleotide phosphate fluxes

Goldbach-Mansky R, Wilson M, Fleischmann R, Olsen N, Silverfield J, Kempf P, Kivitz A, Sherrer Y, Pucino F, Csako G, Costello R, Pham TH, Snyder C, van der Heijde D, Tao X, Wesley R, Lipsky PE

The combination of oral and topical curcumin application demonstrated synergistic effects on multiple skin parameters

My ankle would swell after simple workouts, feel stiff during hikes, and the pain often lingered for days

And do all fibrotic fibroblasts deposit the same ECM constituents or exert the same contractile forces, or is collaboration between multiple ECM fibroblast states necessary for fibrosis