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In the November 2011 final rule (76 FR 67920 through 67922), we adopted an alternate payment methodology that excluded Indirect Medical Education (IME) and Disproportionate Share Hospital (DSH) payments from ACO benchmark and performance year expenditures due to concerns that the inclusion of these amounts would incentivize ACOs to avoid referring patients to the types of providers that receive these payments

The sample included both males and females (68% boys), children with major neurological syndromes, severe developmental delay, sensory impairments, or medical conditions were excluded

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Additional research is necessary to investigate the function of each component in improving health and elucidating its protective effects on different organs

This is crucial as NF-B plays a pivotal role in regulating pro-inflammatory gene expression