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Speed matters too

Journal of Industrial and Engineering Chemistry, 97 , 163172

Thus, the perfect coordination between the consumption and production of energy molecules relies on the complementary roles of ADP and calcium which act as signalling molecules to meet energy demand

141 Notably, it has been reported that the first extracellular domains of claudin-2 and claudin-4 are a key determinant of paracellular charge selectivity and barrier function, but these domains are not involved in the formation of tight junction strands

This review integrates current evidence on how brain peptides contribute to AD pathophysiology, summarizes recent progress in peptide-based therapeutic strategies and delivery platforms, and critically examines the remaining barriers to clinical translation, including bloodbrain barrier penetration, metabolic stability, off-target effects, and the need for biomarker-guided patient stratification