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Additionally, HBV infection also upregulates the expression of unidirectional transport proteins, increasing mitochondrial calcium ion uptake, which enhances membrane permeability, making cells more sensitive to ROS [178]

Hauner, H., Schmid, P

Compared to exercise-induced physiological cardiac hypertrophy, intensive exercise training was found to induce pathological alterations in the cardiovascular system at functional, structural, and molecular levels