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Metabolic disorders Metabolic disorders are a group of diseases that change the normal metabolic process, which can affect the function of sugars, fats, proteins, enzymes in the body, thus affecting metabolism

such as the Chediak-Higashi and Hermansky-Pudlak syndromes, thromboxane A2 dysfunction, Glanzmann thromblastemia, and Bernard-Soulier syndrome) and hereditary hemorrhagic telangiectasias, also known as Rendu-Osler-Weber syndrome

However, Maiorino and co-workers recently redefined the catalytic motif of GPx1 as tetrad by establishing through mutagenesis study in Drosophila model that asparagine (Asn or N) residue was also essential for the catalytic activity of GPx1 [13]

2) is widely accepted, and several inducers of this type of erythrocyte death have been described, including the antiinflammatory compounds Bay 11-7082, parthenolide, and dimethyl fumarate [113], H 2 O 2 [114], the food additive E407a (semi-refined carrageenan) [115], and the tricyclic antidepressant desipramine [116]

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