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Encourages a pro-growth micro-environment, tipping signals toward active growth and away from inhibitory cues

To ensure the generalizability and reliability of these models, researchers employ validation techniques such as cross-validation and external validation

These approaches include reversing the polarization of M2 macrophages to M1, targeting immune checkpoints using checkpoint inhibitors to rebut T cell responses, and implementing cytokine therapy

This response requires an immense amount of cellular energy and rapidly burns through the body's stored micronutrients