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No evident dose-response relationship between cellular ROS level and its cytotoxicity-a paradoxical issue in ROS-based cancer therapy

2017), natural alkaloid berberine can inhibit the progression of the disease [Wu et al

10.1016/j.phymed.2023.154706 282 YassineH

Because of glutaredoxin's similarities to thioredoxin, the mutated protein may be immediately exapted into the thioredoxin-dependent redox cycle upon addition of the second cysteine