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Effectiveness: One study in 60 overweight women demonstrated that those taking 176 mg of saffron extract per day experienced a significant reduction in snacking and lost more weight than women on a placebo pill ( Though these results are promising, larger and longer-term studies must be carried out to understand saffrons role in appetite reduction and weight loss

Marrakchi S, Guigue P, Renshaw BR, et al

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Briefly, cells were lysed in RIPA buffer (20 mM Tris-HCl pH 7.5, 150 mM NaCl, 1 mM EDTA, 1 m M EGTA, 1% NP-40, 1% sodium deoxycholate, 2.5 mM sodium pyrophosphate, 1 mM -glycerophosphate, 1 mM Na 3 VO 4 , and 1 g/ml leupeptin, 1 mM PMSF), and total cellular protein was extracted and quantitated

Kalec et al