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Creatinine level in the blood varies with your muscle mass, so you see higher creatinine levels in men than women

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[0001770] In some embodiments, the detectable agent may be a non-detectable precursor that becomes detectable upon activation (e.g., fluorogenic tetrazine-fluorophore constructs (e.g., tetrazine-BODIPY FL, tetrazine-Oregon Green 488, or tetrazine- BODIPY TMR-X) or enzyme activatable fluorogenic agents (e.g., PROSENSE (VisEn Medical)))

doi: 10.2337/db07-1476 66 DushayJChuiPCGopalakrishnanGSVarela-ReyMCrawleyMFisherFMet al