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Rhee SG, Kil IS

The main limitations of these studies related to the potential for non-differential exposure misclassification, lack of repeat exposure assessments in all studies (although in a subgroup of the CPS-II in the USA, it was shown that high consumption of artificially sweetened beverages was stable over 17 years), and lack of detailed information on aspartame consumption from sources other than artificial beverages (although artificially sweetened beverages are estimated to capture most of the aspartame consumption in the USA during the time periods when the studies were conducted)

Alpha Arbutin is generally well-tolerated and less irritating

Unlabelled controls were generated by incubating cells as described above, however in the absence of 2-NBDG

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